MarrApose Stem Cell Therapy
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MarrApose Stem Cell Therapy


Our mission is to offer autologous stem cell therapies for the treatment of pain that are safe, effective, legal, and affordable.

Our Best Option: MarrApose Stem Cell Therapy using Lumostem Activation.

Please enjoy this 30 minute presentation on our technology!.

Advanced Rejuvenation is one of the first clinics to offer the combination of bone marrow and adipose derived stem cells in a combination treatment. Why is this important? As we age our bone marrow produces less stem cells however there are stem types of stem cells that both favor differentiation into cartilage as well as helping to create new blood supply called neovascularization. By combining these factors all together you are receiving the best science and the new age of stem cell orthopedic has to offer. Besides it being extremely difficult to find a clinic that will offer you both of these cuting edge therapies together when you do find one the expense might suprise you. Advanced Rejuvenation has decided to keep our costs reasonable, so much so you might be able to receive this treatment for 2 or 3 joints at the same time. Since our first cases we have seen promising results from pain and dysfunction associated with cartilage loss in the hip, ankle, knee, and shoulder using MarrApose.
Our own tissues are rich in growth factors and stem cells. When used therapeutically, they are called “autologous stem cells”. “Autologous” means donor and recipient are the same person. Autologous stem cells are not embryonic stem cells; they are ‘adult’ stem cells, or more accurately, ‘tissue’ stem cells that come from your own body.
“Bone-on-bone” arthritis
Chronic Back and neck pain
Overuse and sports injuries


Bone marrow is rich in growth factors and stem cells; primarily hematopoietic stem cells. Bone marrow is harvested from the iliac crest (low back/hip) using local anesthetic and a specialized needle. The bone needle is placed using X-Ray guidance to ensure safety and maximum cell harvest. It is important to understand that bone marrow harvesting for BMAC is vastly different from bone marrow harvesting for transfusion for cancer therapies. In bone marrow harvesting for transfusion, a surgeon removes a very large amount of bone marrow from many puncture sites. BMAC requires only a very small amount of bone marrow from one or two puncture sites. The procedure is extremely safe; we have performed many of them without a single adverse outcome. Surprisingly, it is not painful, takes under twenty minutes, and causes only mild soreness afterward. It has an excellent safety profile.


Adipose tissue (fat) consists of adipocytes (fat cells) and the adipose-derived stromal vascular fraction (SVF). The SVF is made up largely of mesenchymal cells. In addition to the potential therapeutic benefit of the SVF, when injected into joints, the adipocytes have the potential to act as a scaffold to allow for regeneration of connective tissue to occur. Fat harvesting for SVF therapy is done with a very simple process called lipoaspiration. It is important to understand that lipoaspiration is vastly different from liposuction. Liposuction is performed by a plastic surgeon that removes a very large volume of fat for a cosmetic result. Lipoaspiration uses a small amount of local anesthetic and a small instrument slightly larger than a hypodermic needle to remove a very small amount of fat, and does not render any visible change in appearance. The fat is then concentrated using a simple, sterile gravity method using only sterile saline to rinse the tissue. The entire process is painless and takes about 45 minutes.


In 2006, David Crane, M.D. and Robert Alexander, M.D. first blended bone marrow aspirate concentrate (BMAC) with adipose tissue into a localized injection for the treatment of musculoskeletal pain conditions. Crane and Alexander’s thinking was that the combination of the two tissues could potentially render a superior outcome than either of the tissues individually. Their clinical experience supported the hypothesis. In 2008 the team at Advanced Rejuvenation began providing this treatment. Take a look at this recent study on using both BMAC and ADSC (both).
Of the small number of doctors performing autologous stem cell therapies in the US, few of them combine BMAC with adipose. Most prolotherapists use platelet rich plasma with adipose only and most surgeons use BMAC only. Many who use adipose claim it to be superior to bone marrow and point to the higher volume of stem cells in adipose. Many who use bone marrow claim bone marrow to be superior to adipose and point to the much larger body of scientific data supporting bone marrow’s use. The truth is, there is not currently sufficient research to definitively say that one is superior to the other. Advanced Rejuvenation is among the very small number of clinics in the US who combine BMAC with adipose. Although we do not yet have publishable data, we have been pleased with our degree of patient satisfaction since early 2010.

View this article to read more about the comparison between adipose and bone marrow stem cells .

Avoid Surgery Using Stem Cells

This was a 2 yr follow up with a woman who had osteoarthritis of her knee joints. After stem cells from fat and bone marrow and PRP which is using ones own blood factors to stimulate a regenerative effect in the body, she was pain free. This is a way for you to avoid painful surgery. stem cells is minimally invasive and little to no down time needed.

Why Choose Advanced Rejuvenation?


Advanced Rejuvenation emphasizes quality and our well trained physicians are highly committed to the advancement of regenerative medicine.

Industry Leaders

Our team is a fusion of Medical, Osteopathic, Chiropractic, Podiatric and Eastern Medicine doctors who helped shape the industry.

Over 50+ Years Combined Experience

Our doctors have been perfecting these procedures together for over 10 years. You’re in good hands.

Cutting Edge Technology

We offer patented procedures that are only available at Advanced Rejuvenation.

What Are My Next Steps?


A fresh start to arthritic joints starts here. Find out what we can do for you.

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