Applications of Mesenchymal stem cell-based therapies in Rheumatoid Arthritis.
Rheumatoid arthritis is chronic autoimmune systematic inflammatory disease of connective tissue with predominant joint disease of erosive-destructive progressive polyarthritis type. The pathogenesis basis of rheumatoid arthritis consist of genetically determined autoimmune processes, which are caused by deficit of T- suppressor function of lymphocytes.
MSCs also display immunosuppressive properties, which suppress local inflammation and tissue damage in inflammatory autoimmune diseases.
Stem cells and specifically, mesenchymal stem cells with their immunoregulatory characteristics, differentiation capacity and trophic potential home to inflamed tissue and start producing anti-inflammatory agents. These mediators act locally and do not suppress the immune response of the patient’s whole body. Autologous stem cells derived from bone marrow or adipose tissue induce the production of T regulatory cells, a type of immune cell whose function is to protect the body against immunological self-attack.
Rheumatoid arthritis is chronic autoimmune systematic inflammatory disease of connective tissue with predominant joint disease of erosive-destructive progressive polyarthritis type. The pathogenesis basis of rheumatoid arthritis consist of genetically determined autoimmune processes, which are caused by deficit of T- suppressor function of lymphocytes.
MSCs also display immunosuppressive properties, which suppress local inflammation and tissue damage in inflammatory autoimmune diseases.
Stem cells and specifically, mesenchymal stem cells with their immunoregulatory characteristics, differentiation capacity and trophic potential home to inflamed tissue and start producing anti-inflammatory agents. These mediators act locally and do not suppress the immune response of the patient’s whole body. Autologous stem cells derived from bone marrow or adipose tissue induce the production of T regulatory cells, a type of immune cell whose function is to protect the body against immunological self-attack.
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