The epidemic proportions of heart failure together with limitations in its treatment constitute the bases for the recent interest and enthusiasm in regenerative cardiology. Our efforts in this field aim at the reconstitution of the myocardium or vascular structures lost upon pathological insults, and involve the utilization of cell treatments, exosome products, chelation, oxygen and tissue engineering. Soon after the first experimental evidence that bone marrow-derived cells (BMCs) induce cardiac repair in the postinfarcted heart, endothelial progenitor cells, mononuclear bone marrow cells and exosomes have been administered to patients affected by acute myocardial infarction or chronic ischemic heart failure. These interventions had positive outcomes documenting not only the feasibility and safety of this therapeutic approach but also beneficial effects on cardiac function. Advanced Rejuvenation is at the forefront of the science of Regenerative Cardiology.