14 Oct Do exosomes have more therapeutic promise than stem cells?

Exosomes have shown great promise as potential therapeutics and as vehicles to carry trophic payloads to the site of injury or disease.

They:

• Are micro-sized biologics produced by stem cells

• Act as cell-to-cell messengers

• Contain bio-molecular cargo of RNA, DNA, miRNA and Proteins

• Bleb or bubble off cells during growth and differentiation and serve as master regulators for cellular signaling

• Have the potential to target any cell in the body

• Can cross the blood-brain barrier

• Have the potential to “home” to a site of injury or disease and initiate repair

The placental stem cell-derived exosomes have demonstrated the ability to:

• Cross the blood-brain barrier non-invasively to reach the site of injury

• Enable multiple intravenous (IV) dosing without adverse response

• Reduce inflammation and inflammatory signals and provide functional improvement in preclinical studies.